Яндекс Маркет

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Яндекс Яндекс

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Надежда Бабикова

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15 ответов

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Дачник 10 уровня

Дача, сад и огород

Мастер на все руки 10 уровня

Строительство и ремонт

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Для лечения инфекции, вызванной Herpes simplex, при клиренсе креатинина менее 10 мл/мин суточную дозу препарата следует уменьшить до 400 мг, разделив ее на 2 приема (с интервалами между ними не менее 12 ч, т.е. по 200 мг 2 раза в сутки).\u003Cbr\u003EПри лечении инфекций, вызванных Varicella zoster, и при поддерживающей терапии больных с выраженным иммунодефицитом - пациентам с клиренсом креатинина 10-25 мл/мин назначают препарат по 800 мг 3 раза в сутки с интервалом 8 ч, с клиренсом креатинина менее 10 мл/мин - по 800 мг 2 раза в сутки с интервалом 12 ч."},{"description":"","filters":[{"id":15767998,"name":"Побочные действия"}],"isMainProperty":false,"name":"Побочные действия","value":"Со стороны пищеварительной системы: тошнота, рвота, диарея, боли в животе; редко - обратимое повышение содержания билирубина и активности печеночных ферментов.\u003Cbr\u003EСо стороны системы кроветворения: очень редко - анемия, лейкопения, тромбоцитопения.\u003Cbr\u003EСо стороны мочевыделительной системы: редко - повышение содержания мочевины и креатинина в крови; очень редко - острая почечная недостаточность.\u003Cbr\u003EСо стороны центральной нервной системы: головная боль, слабость, головокружение, повышенная утомляемость, спутанность сознания, галлюцинации, сонливость, парестезии, судороги, снижение концентрации внимания, ажитация.\u003Cbr\u003EАллергические реакции: зуд, сыпь, синдром Лайелла, крапивница, мультиформная экссудативная эритема, в т.ч. синдром Стивенса-Джонсона, ангионевротический отек, анафилаксия.\u003Cbr\u003EПрочие: лихорадка, лимфоаденопатия, периферические отеки, нарушение зрения, миалгия, алопеция."},{"description":"","filters":[{"id":15768001,"name":"Фармакологическое действие"}],"isMainProperty":false,"name":"Фармакологическое действие","value":"Противовирусный препарат - синтетический аналог ациклического пуринового нуклеозида, обладающий высоко избирательным действием на вирусы герпеса. В инфицированных клетках, содержащих вирусную тимидинкиназу, происходит фосфорилирование и превращение в ацикловира монофосфат. Под влиянием гуанилатциклазы ацикловира монофосфат преобразуется в дифосфат и под действием нескольких клеточных ферментов - в трифосфат.\u003Cbr\u003EАцикловир трифосфат встраивается в цепочку вирусной ДНК и блокирует ее синтез посредством конкурентного ингибирования вирусной ДНК-полимеразы. Специфичность и весьма высокая селективность действия также обусловлены преимущественным его накоплением в клетках, пораженных вирусом герпеса.\u003Cbr\u003EВысокоактивен в отношении вируса Herpes simplex 1 и 2 типов; вируса, вызывающего ветряную оспу и опоясывающий лишай (Varicella zoster); вируса Эпштейна-Барр. Умеренно активен в отношении цитомегаловируса.\u003Cbr\u003EПри герпесе предупреждает образование новых элементов сыпи, снижает вероятность кожной диссеминации и висцеральных осложнений, ускоряет образование корок, снижает боль в острой фазе опоясывающего герпеса."},{"description":"","filters":[{"id":34045110,"name":"Фармакологическая группа"}],"isMainProperty":false,"name":"Фармакологическая группа","value":"противовирусное средство"},{"description":"","filters":[{"id":27141511,"name":"Форма выпуска для карточки"}],"isMainProperty":false,"name":"Форма выпуска","value":"таблетки"},{"description":"","filters":[{"id":35947170,"name":"Способ применения/введения"}],"isMainProperty":false,"name":"Способ применения/введения","value":"пероральный"},{"description":"","filters":[{"id":23679511,"name":"Минимальный возраст применения"},{"id":16082123,"name":"С рождения"}],"isMainProperty":false,"name":"Минимальный возраст применения","value":"от 3 лет"}]},{"name":"Дополнительно","specs":[{"description":"","filters":[{"id":15767999,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"В сухом, защищенном от света месте при температуре не выше 25 °С.\u003Cbr\u003EХранить в недоступном для детей месте."},{"description":"","filters":[{"id":15768014,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Симптомы: ажитация, кома, судороги, летаргия. Возможна преципитация ацикловира в почечных канальцах, если его концентрация превышает растворимость в почечных канальцах(2,5 мг/мл).\u003Cbr\u003EЛечение: симптоматическое."},{"description":"","filters":[{"id":15768015,"name":"Применение при беременности и кормлении грудью"}],"isMainProperty":false,"name":"Применение при беременности и кормлении грудью","value":"Применение во время беременности возможно только в том случае, когда предполагаемая польза для матери превышает потенциальный риск для плода.\u003Cbr\u003EПри необходимости применения препарата в период лактации следует прекратить грудное вскармливание."},{"description":"","filters":[{"id":17360993,"name":"Влияние на способность управлять транспортом и механизмами"}],"isMainProperty":false,"name":"Влияние на способность управлять транспортом и механизмами","value":"В период лечения необходимо соблюдать осторожность при управлении транспортными средствами и занятии другими потенциально опасными видами деятельности/ требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"description":"","filters":[{"id":15771167,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"С осторожностью:\u003Cbr\u003EБеременность, пожилой возраст, дегидратация, почечная недостаточность, неврологические нарушения или неврологические реакции на прием цитотоксичных лекарственных средств (в т.ч. в анамнезе).\u003Cbr\u003EПри приеме препарата следует контролировать функцию почек (содержание мочевины крови и креатинина плазмы крови).\u003Cbr\u003EПри применении препарата необходимо обеспечить поступление достаточного количества жидкости.\u003Cbr\u003EДлительное или повторное лечение ацикловиром больных со сниженным иммунитетом может привести к появлению штаммов вирусов, нечувствительных к его действию. У большинства выделенных штаммов вирусов, нечувствительных к ацикловиру, обнаруживается относительная нехватка вирусной тимидинкиназы; были выделены штаммы с измененной тимидинкиназой или с измененной ДНК-полимеразой. In vitro действие ацикловира на изолированные штаммы вируса Herpes simplex может вызвать появление менее чувствительных штаммов.\u003Cbr\u003EАцикловир не предупреждает передачу герпеса половым путем, поэтому в период лечения необходимо воздерживаться от половых контактов, даже при отсутствии клинических проявлений."},{"description":"","filters":[{"id":15768012,"name":"Взаимодействие"}],"isMainProperty":false,"name":"Взаимодействие","value":"При одновременном применении с пробенецидом увеличивается средний период полувыведения и снижается клиренс ацикловира.\u003Cbr\u003EПри одновременном применении с нефротоксическими препаратами повышается риск развития нарушений функций почек."},{"description":"","filters":[{"id":16435314,"name":"Регистрационный номер"}],"isMainProperty":false,"name":"Регистрационный номер","value":"ЛC-000044"},{"description":"","filters":[{"id":16435315,"name":"Дата государственной регистрации"}],"isMainProperty":false,"name":"Дата государственной 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В случае возникновения аллергической реакции следует прекратить прием препарата и обратиться к врачу.\u003Cbr\u003E\nСо стороны пищеварительной системы: боли в желудке, кишечнике, запор, диарея, метеоризм, тошнота, рвота.\u003Cbr\u003E\nСо стороны нервной системы: головная боль, головокружение, бессонница, нервозность.\u003Cbr\u003E\nМетаболические нарушения: гиперкальциурия."},{"description":"","filters":[{"id":50921468,"name":"Передозировка"}],"isMainProperty":false,"name":"Передозировка","value":"Поскольку Супрадин содержит жирорастворимые витамины А и D, признаки острой или хронической передозировки могут развиться после однократного приема препарата в высокой дозе или при длительном применении.\u003Cbr\u003EСимптомы: внезапные приступы головной боли, головокружение, спутанность сознания, а также расстройства ЖКТ, включая тошноту, диарею или запоры.\u003Cbr\u003EУ некоторых пациентов с дефицитом глюкозо-6-фосфатдегидрогеназы передозировка витамина C (более 15 г) может вызывать гемолитическую анемию.\u003Cbr\u003EЛечение: при возникновении указанных симптомов пациенту необходимо немедленно прекратить прием препарата и обратиться к врачу. При случайном приеме более 12 таблеток для детей (масса тела 12 кг) и более 60 таблеток для взрослых (масса тела 60 кг) следует вызвать рвоту или промыть желудок. Терапия симптоматическая, специфический антидот отсутствует."},{"description":"","filters":[{"id":50921467,"name":"Условия хранения"}],"isMainProperty":false,"name":"Условия хранения","value":"Препарат следует хранить в защищенном от нагревания и влаги, недоступном для детей месте при температуре не выше 25°С."},{"description":"","filters":[{"id":50921466,"name":"Особые указания"}],"isMainProperty":false,"name":"Особые указания","value":"Пациенты, принимающие другие лекар¬ственные средства, должны проконсульти-роваться с врачом перед тем, как начать прием препарата Супрадин.\u003Cbr\u003E\nРекомендуемая доза препарата не должна быть превышена, поскольку очень высокие дозы некоторых ингредиентов препарата, в частности витамина А, витамина D, железа и меди могут оказывать неблагоприятное воздействие на организм человека. Так, чрезмерный прием витамина А в короткие сроки в дозировке более 500000 ME приво¬дит к острому гипервитаминозу, выражающемуся в недомогании, боли в животе, го¬ловной боли с тошнотой и рвотой, головокружении.\u003Cbr\u003E \nДлительный прием витамина А в дозировке более 100000 МЕ/день приводит к хроническому гипервитаминозу, проявляющемуся костной и суставной болью, сухостью кожи и ломкостью ногтей, выпадением волос и потерей веса. Избыточный прием витамина D в дозировке 2000 ME в течение нескольких недель или месяцев также приводит к гипервитаминозу, симпомами которого являются тошнота, рвота, жажда, нарушение стула, обезвоживание.\u003Cbr\u003E\nНаличие в препарате рибофлавина может вызвать окрашивание мочи в ярко-желтый цвет, что совершенно безвредно. Кальций, аскорбиновая кислота и витамин D могут влиять на образование камней, поэтому пациенты с нефролитиазом или мочекаменной болезнью должны соблюдать осторожность при приеме витаминно минеральных комплексов."},{"description":"","filters":[{"id":32849454,"name":"Страна бренда"}],"isMainProperty":false,"name":"Страна бренда","value":"Германия"},{"description":"","filters":[{"id":16064056,"name":"Страна производства"}],"isMainProperty":false,"name":"Страна производства","value":"Германия"},{"description":"","filters":[{"id":34362170,"name":"Владелец регистрационного удостоверения"}],"isMainProperty":false,"name":"Владелец регистрационного удостоверения","value":"Bayer"},{"description":"","filters":[{"id":35771390,"name":"Изготовитель"}],"isMainProperty":false,"name":"Изготовитель","value":"Dragenopharm Apotheker Puschl"},{"description":"","filters":[{"id":34543370,"name":"Фасовщик"}],"isMainProperty":false,"name":"Фасовщик","value":"Dragenopharm Apotheker 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